Scotland's Rural College has plans to downsize its campus near Cupar and change its animal care courses.
It will leave the main building at Elmwood at the end of term.
It is understood the building has become too expensive to run and will likely be torn down.
Students can use other buildings on the campus, but many are concerned the move will harm their learning.
A statement issued by the college on Friday said: “On February 21, a meeting was held with colleagues at our Elmwood Campus in Fife to share plans for the future development of the campus.
“To ensure that Elmwood is financially sustainable and continues to thrive as an integral part of SRUC into the future, we need to reduce the physical footprint of the campus.
“Regrettably, this means that we will exit the main building at the end of this term and we will utilise Elmwood House and our horticultural facilities to deliver our courses going forward.”
It added: “As a result of exiting the main building, there will be implications for the way animal care courses are delivered.
“But as we have said in consultation with staff, students and with trade unions since last year, we are working with staff to develop a new and different – and financially viable – delivery model for animal care.
“We want to ensure the core delivery of this subject continues at Elmwood.
“These changes are designed to ensure that we continue to support our students and (the) broader community in Elmwood.
“An important feature of our plans for Elmwood is the introduction of a new academic model that will include new courses to be implemented from September 2024.
“We will strive to minimise job losses as a result of these changes and, over the coming weeks, we will continue to provide updates as we work towards creating a financially sustainable and vibrant Elmwood, with a focus on creating the best possible service and environment for our students, local community and business.”
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